would, Child, hemophiliac



by GothEric

Question by J:

What sex would the hemophiliac child be?

Hemophila B is sex-linked and recessive in humans. A heterozygous woman marries a normal man, is it possible for them to have a hemophiliac child? If so, what sex would the hemophiliac child be?




Best answer:

Answer by bradlepe
Yes, male.

The say it's sex-linked, so that means the gene is either on the X or Y chromosome.

They then say that the mother is heterozygous, so it must be on the X chromosome (in order for her to be heterozygous, she needs to have one copy of the normal allele and another of the disease-associated allele). If it were Y-linked, the father would be hemizygous for the allele (since he only has one copy of the Y chromosome) and he would also have the disease.

When they mate, their daughters will get one X chromosome from the mother and the other from the father. Since the father doesn't have the disease, the X chromosome they get from him will have to have the normal allele, so none of the females will have the disease.

For their sons, the father gives them his Y chromosome and the mother gives one of her two X chromosomes. If a son gets the X chromosome that has the disease-associated allele, he'll have the disease since he didn't inherit a normal copy from his father.

What do you think? Answer below!




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